Non-Genetic Influences on Cystic Fibrosis Lung Disease: The Role of Sociodemographic Characteristics, Environmental Exposures, and Healthcare Interventions

Abstract excerpt

Patients with cystic fibrosis (CF) exhibit significant variability in the course and severity of the disease, and this variability is best interpreted in the context of an interaction between genetic and nongenetic determinants. While a small number of patients with "mild" mutations in the CF transmembrane conductance regulator gene clearly have less severe disease, for the general population of patients with CF...

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