Article
Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.
Journal of medical virology - 1 Oct 2017
Dos Santos Maria Isabel Magalhães A, Pacheco Sidelcina Rugieri, Stocker Andreas, Schinoni Maria Isabel, Paraná Raymundo, Reis Mitermayer G, Silva Luciano K
Abstract excerpt
The Brazilian public health system (SUS) has provided antiviral drugs for chronic hepatitis B treatment for over 10 years, but a system for monitoring for drug-related resistance mutations is not available. Determine the presence of HBV mutations associated with resistance to nucleos(t)ide analogs among 81 patients with chronic HBV infection in Salvador-BA-Brazil. HBV-DNA was PCR amplified with primers deduced...
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