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Article

p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.

The Journal of biological chemistry - 6 Feb 2004

Liu Yu, Wu Chaowei, Galaktionov Konstantin

Abstract excerpt

The cyclin-dependent kinase (CDK)-activating kinase (CAK) phosphorylates a conserved threonine residue on CDKs and activates them. Two known classes of CAKs are represented by monomeric Cak1p in budding yeast Saccharomyces cerevisiae and by heterotrimeric CDK7-cyclin H-Mat1 in human and other metazoa. We report here the identification of p42, a novel CAK activity in human cells. p42 has sequence homology to both...

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Identifiers

PMID: 14597612
DOI: 10.1074/jbc.M309995200

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CDK2
CDK7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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