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Article

Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs.

Nature protocols - 1 Jun 2017

Sanders Ashley D, Falconer Ester, Hills Mark, Spierings Diana C J, Lansdorp Peter M

Abstract excerpt

The ability to distinguish between genome sequences of homologous chromosomes in single cells is important for studies of copy-neutral genomic rearrangements (such as inversions and translocations), building chromosome-length haplotypes, refining genome assemblies, mapping sister chromatid exchange events and exploring cellular heterogeneity. Strand-seq is a single-cell sequencing technology that resolves the...

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PMID: 28492527
DOI: 10.1038/nprot.2017.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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