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Cascade screening in HBOC and Lynch syndrome: guidelines and procedures in a UK centre.

Familial cancer - 1 Jun 2024

Evans D Gareth, Green Kate, Burghel George J, Forde Claire, Lalloo Fiona, Schlecht Helene, Woodward Emma R

Abstract excerpt

In the 33 years since the first diagnostic cancer predisposition gene (CPG) tests in the Manchester Centre for Genomic Medicine, there has been substantial changes in the identification of index cases and cascade testing for at-risk family members. National guidelines in England and Wales are usually determined from the National Institute of healthcare Evidence and these have impacted on the thresholds for...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hereditary Breast and Ovarian Cancer Syndrome

Share to Mismatch Repair Endonuclease PMS2

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Source

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Identifiers

PMID: 38478259
DOI: 10.1007/s10689-024-00360-9
PMCID: PMC11153258

Genes

BRCA1
BRCA2
MLH1
MSH2
MSH6
PMS2

Provenance

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