Performance of PREMM5, clinical criteria, and immunohistochemistry for MMR proteins in genetic risk assessment of Mexican patients with colorectal cancer.

doi:10.1371/journal.pone.0354795

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Article

Performance of PREMM5, clinical criteria, and immunohistochemistry for MMR proteins in genetic risk assessment of Mexican patients with colorectal cancer.

PloS one - 1 Jan 2026

Rodríguez-Olivares José Luis, Aguilar-Y-Méndez Dione, Kimball Tamara N, Rivero-García Pamela, Rios-Valencia Javier, Santuario-Facio Sandra, Rojas-Martinez Augusto, Ortiz-López Rocío, Barraza-Arellano Angélica Leticia, Aranda-Gutierrez Alejandro, Arteaga-Vazquez Jazmín, De-La-Mora-Molina Héctor, Herzog Josef, Jeter Joanne M, Weitzel Jeffrey N, Chávarri-Guerra Yanin

Abstract excerpt

BACKGROUND: All individuals with colorectal cancer (CRC) should undergo genetic cancer risk assessment given its implications for personalized treatment, surveillance, risk-reduction strategies, and cascade testing. Universal screening using immunohistochemistry (IHC) for mismatch repair (MMR) proteins in tumor tissue, when combined with clinical criteria, is essential for identifying individuals at higher risk...

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Identifiers

PMID: 42550852
DOI: 10.1371/journal.pone.0354795
PMCID: PMC13436770

Genes

ATM
BRCA1
BRCA2
BRIP1
CHEK2
MLH1
MSH2
MSH6
MUTYH
PALB2
PMS2
TP53

Provenance

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