Article
Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.
Cancer cell - 8 May 2017
Zhang Shihao, Chen Qinghua, Liu Qingxu, Li Yuxi, Sun Xiufeng, Hong Lixin, Ji Suyuan, Liu Chengyan, Geng Jing, Zhang Weiji, Lu Zhonglei, Yin Zhen-Yu, Zeng Yuanyuan, Lin Kwang-Huei, Wu Qiao, Li Qiyuan, Nakayama Keiko, Nakayama Keiich I, Deng Xianming, Johnson Randy L, Zhu Liang, Gao Daming, Chen Lanfen, Zhou Dawang
Abstract excerpt
Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-mediated acetylation of the E3 ligase Skp2 via Akt signaling. Acetylated Skp2 is exclusively localized to the cytosol, which causes hyper-accumulation of the...
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