Article
Klotho protects human monocytes from LPS-induced immune impairment associated with immunosenescent-like phenotype.
Molecular and cellular endocrinology - 15 Jul 2018
Mytych Jennifer, Romerowicz-Misielak Maria, Koziorowski Marek
Abstract excerpt
In this study, we provide a new evidence on immunosenescent-like phenotype induction in low density monocytes due to the long-term treatment with lipopolysaccharide (LPS). We show that LPS caused oxidative and nitrosative stress through zinc downregulation and calcium accumulation. In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFα, IL-1β, IL-6 led to the irreversible DNA damage, persistent...
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