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Article

Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains.

Biochimica et biophysica acta. Biomembranes - 1 Aug 2017

Alberga Domenico, Trisciuzzi Daniela, Lattanzi Gianluca, Bennett Jeffrey L, Verkman Alan S, Mangiatordi Giuseppe Felice, Nicolotti Orazio

Abstract excerpt

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system in which most patients have serum autoantibodies (called NMO-IgG) that bind to astrocyte water channel aquaporin-4 (AQP4). A potential therapeutic strategy in NMO is to block the interaction of NMO-IgG with AQP4. Building on recent observation that some single-point and compound mutations of the AQP4 extracellular...

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Source

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Identifiers

PMID: 28477975
DOI: 10.1016/j.bbamem.2017.05.001
PMCID: PMC5581535

Genes

AQP4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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