Article
HIF-1α 1772 C/T and 1790 G/A polymorphisms are significantly associated with higher cancer risk: an updated meta-analysis from 34 case-control studies.
PloS one - 1 Jan 2013
Yang Xi, Zhu Hong-Cheng, Zhang Chi, Qin Qin, Liu Jia, Xu Li-Ping, Zhao Lian-Jun, Zhang Qu, Cai Jing, Ma Jian-Xin, Cheng Hong-Yan, Sun Xin-Chen
Abstract excerpt
BACKGROUND: HIF-1 activates various genes in cancer progression and metastasis. HIF-1α 1772 C/T and 1790 G/A polymorphisms are reportedly associated with cancer risk; however, the results are inconclusive. METHODOLOGY/PRINCIPAL FINDINGS: A meta-analysis of 34 studies that involved 7522 cases and 9847 controls for 1772 C/T and 24 studies that involved 4884 cases and 8154 controls for 1790 G/A was conducted to...
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