Article
MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1.
Cell death and differentiation - 1 Jul 2017
Shen Hongxing, Xing Chuan, Cui Kaisa, Li Yunxiao, Zhang Jinxiang, Du Runlei, Zhang Xiaodong, Li Youjun
Abstract excerpt
Frequent KRAS mutations contribute to multiple cancers including ~40% of human colorectal cancers (CRCs). Systematic screening of 1255 microRNAs (miRNAs) identified miR-30a as a synthetic lethal in KRAS-mutant CRC cells. miR-30a was downregulated in CRCs and repressed by P65. miR-30a directly targeted malic enzyme 1 (ME1) and KRAS, and inhibited anchorage-independent growth and in vivo tumorigenesis by...
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