Article
Helix-Coil Transition Signatures B-Raf V600E Mutation and Virtual Screening for Inhibitors Directed Against Mutant B-Raf.
Current drug metabolism - 21 Jul 2017
Bandaru Srinivas, Sumithnath Tharaparambil Gangadharan, Sharda Saphy, Lakhotia Sanskruti, Sharma Anudeep, Jain Amrita, Hussain Tajamul, Nayarisseri Anuraj, Singh Sanjeev Kumar
Abstract excerpt
BACKGROUND: Mutation in the B RAF at V600E has been well implicated in the carcinogenesis that makes it as an attractive therapeutictarget. In the present study, we sought to identify the basis of V600E mutation at functional and structural grounds. The study also endeavors in identification of small molecule as a potential candidate with considerable pharmacological profile than available BRAF inhibitors through...
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