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Article

De Novo Coding Variants Are Strongly Associated with Tourette Disorder.

Neuron - 3 May 2017

Willsey A Jeremy, Fernandez Thomas V, Yu Dongmei, King Robert A, Dietrich Andrea, Xing Jinchuan, Sanders Stephan J, Mandell Jeffrey D, Huang Alden Y, Richer Petra, Smith Louw, Dong Shan, Samocha Kaitlin E, Neale Benjamin M, Coppola Giovanni, Mathews Carol A, Tischfield Jay A, Scharf Jeremiah M, State Matthew W, Heiman Gary A

Abstract excerpt

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186 trios from the Tourette Syndrome Association International Consortium on Genetics (511 total). We observe strong and...

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Identifiers

PMID: 28472652
DOI: 10.1016/j.neuron.2017.04.024
PMCID: PMC5769876

Genes

C2
CELSR3
EGF
FN1
NIPBL
WWC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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