Article
Association Between Polymorphisms in the Purinergic P2Y12 Receptor Gene and Severity of Both Cancer Pain and Postoperative Pain.
Pain medicine (Malden, Mass.) - 1 Feb 2018
Sumitani Masahiko, Nishizawa Daisuke, Nagashima Makoto, Ikeda Kazutaka, Abe Hiroaki, Kato Ryoji, Ueda Hiroshi, Yamada Yoshitsugu
Abstract excerpt
Background: Despite the widespread use of opioids for the treatment of cancer pain, results from several surveys consistently show that pain is still prevalent in some patients with malignant diseases. The purinergic P2Y12 receptor is a primary site leading to microglial activation and hyperalgesic pain behaviors and is considered a key regulator in the prevention of the aggravation of clinical pain conditions....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.