Article
Associations of the Intellectual Disability Gene MYT1L with Helix-Loop-Helix Gene Expression, Hippocampus Volume and Hippocampus Activation During Memory Retrieval.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2017
Kepa Agnieszka, Martinez Medina Lourdes, Erk Susanne, Srivastava Deepak P, Fernandes Alinda, Toro Roberto, Lévi Sabine, Ruggeri Barbara, Fernandes Cathy, Degenhardt Franziska, Witt Stephanie H, Meyer-Lindenberg Andreas, Poncer Jean-Christophe, Martinot Jean-Luc, Paillère Martinot Marie-Laure, Müller Christian P, Heinz Andreas, Walter Henrik, Schumann Gunter, Desrivières Sylvane
Abstract excerpt
The fundamental role of the brain-specific myelin transcription factor 1-like (MYT1L) gene in cases of intellectual disability and in the etiology of neurodevelopmental disorders is increasingly recognized. Yet, its function remains under-investigated. Here, we identify a network of helix-loop-helix (HLH) transcriptional regulators controlled by MYT1L, as indicated by our analyses in human neural stem cells and...
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