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A Targeted Mass Spectrometry Assay for Detection of HIV Gag Protein Following Induction of Latent Viral Reservoirs.

Analytical chemistry - 16 May 2017

Schlatzer Daniela, Haqqani Aiman A, Li Xiaolin, Dobrowolski Curtis, Chance Mark R, Tilton John C

Abstract excerpt

During early infection, HIV-1 establishes a reservoir of latently infected cells that persist during antiretroviral therapy. These reservoirs are considered the primary obstacle to eradicating HIV-1 from patients, and multiple strategies are being investigated to eliminate latently infected cells. Measuring the reservoir size using an affordable and scalable assay is critical as these approaches move into...

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Share to Anti-HIV Agents
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Chromatography, High Pressure Liquid

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Immunoprecipitation

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Source

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PMID: 28467046
DOI: 10.1021/acs.analchem.6b05070

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SRM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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