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Article

Cancer stemness and metastatic potential of the novel tumor cell line K3: an inner mutated cell of bone marrow-derived mesenchymal stem cells.

Oncotarget - 13 Jun 2017

Qian Hui, Ding Xiaoqing, Zhang Jiao, Mao Fei, Sun Zixuan, Jia Haoyuan, Yin Lei, Wang Mei, Zhang Xu, Zhang Bin, Yan Yongmin, Zhu Wei, Xu Wenrong

Abstract excerpt

Mesenchymal stem cells (MSCs) transplantation has been used for therapeutic applications in various diseases. Here we report MSCs can malignantly transform in vivo. The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs (rBM-MSCs) and the new tumor cell line, K3, was isolated from the neoplasm. The K3 cells expressed surface antigens and pluripotent genes...

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Identifiers

PMID: 28465472
DOI: 10.18632/oncotarget.17133
PMCID: PMC5503629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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