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Article

Stem-cell origin of metastasis and heterogeneity in solid tumours.

The Lancet. Oncology - 1 Aug 2002

Tu Shi-Ming, Lin Sue-Hwa, Logothetis Christopher J

Abstract excerpt

An explanation for the inherently metastatic and heterogeneous nature of cancers may be their derivation from distinct stem cells. The type of stem cell from which a neoplasm arises determines both the metastatic potential and the phenotypic diversity of that neoplasm. Hence, tumours originating from an early stem cell or its progenitor cells metastasise readily and have a more heterogeneous phenotype, whereas...

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Identifiers

PMID: 12147437
DOI: 10.1016/s1470-2045(02)00820-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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