Article

Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity

2022-08-05

Abstract excerpt

<title>Abstract</title> <p>Human papillomavirus (HPV) infection is the prime elicitor of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope dismantles. Since lamins safeguard nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. We challenged human cervical cancer cells knocked out for the major lamin g...

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Literature Corpus work: 8598fb91-42b9-5c87-a208-fe6ed9166e1c
DOI: 10.21203/rs.3.rs-1911728/v1

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