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Article

Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.

Proceedings of the National Academy of Sciences of the United States of America - 16 May 2017

Dai Yu-Jun, Wang Yue-Ying, Huang Jin-Yan, Xia Li, Shi Xiao-Dong, Xu Jie, Lu Jing, Su Xian-Bin, Yang Ying, Zhang Wei-Na, Wang Pan-Pan, Wu Song-Fang, Huang Ting, Mi Jian-Qing, Han Ze-Guang, Chen Zhu, Chen Sai-Juan

Abstract excerpt

DNMT3A is frequently mutated in acute myeloid leukemia (AML). To explore the features of human AML with the hotspot DNMT3A R882H mutation, we generated Dnmt3a R878H conditional knockin mice, which developed AML with enlarged Lin-Sca1+cKit+ cell compartments. The transcriptome and DNA methylation profiling of bulk leukemic cells and the single-cell RNA sequencing of leukemic stem/progenitor cells revealed...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to DNA Modification Methylases

Share to Gene Knock-In Techniques

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 28461508
DOI: 10.1073/pnas.1703476114
PMCID: PMC5441829

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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