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Article

OXPHOS toxicogenomics and Parkinson's disease.

Mutation research - 1 Jan 2000

López-Gallardo Ester, Iceta Ruth, Iglesias Eldris, Montoya Julio, Ruiz-Pesini Eduardo

Abstract excerpt

Activities and quantities of several oxidative phosphorylation (OXPHOS) system complexes are decreased in many Parkinson's disease (PD) patients. Mutations in PD-associated nuclear genes affect OXPHOS function. Moreover, the inactivation of other nuclear genes related to mitochondrial DNA (mtDNA) replication and expression also leads to Parkinsonism. MtDNA only encodes OXPHOS subunits and the RNAs required for...

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Identifiers

PMID: 21763451
DOI: 10.1016/j.mrrev.2011.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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