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Article

CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression

29 Apr 2017

Abstract excerpt

Abstract The inflammatory CD40–CD40L pathway is implicated in various autoimmune diseases, but the activity status of this pathway in various stages of rheumatoid arthritis (RA) progression is unknown. In this study, we used gene signatures of CD40L stimulation derived from human immature dendritic cells and naive B cells to assess the expression of CD40-downstream genes in synovial tissues from...

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PMID: 28455435
DOI: 10.4049/jimmunol.1601988

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