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Mitochondrial DNA-depleted A549 cells are resistant to bleomycin

7 Jul 2012

Abstract excerpt

Alveolar epithelial cells are considered to be the primary target of bleomycin-induced lung injury, leading to interstitial fibrosis. The molecular mechanisms by which bleomycin causes this damage are poorly understood but are suspected to involve generation of reactive oxygen species and DNA damage. We studied the effect of bleomycin on mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) in human alveolar...

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PMID: 22773697
DOI: 10.1152/ajplung.00343.2011

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