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Article

Genetic variation in Otos is associated with cisplatin-induced ototoxicity.

Pharmacogenomics - 1 Sept 2014

Spracklen Timothy F, Whitehorn Heather, Vorster Anna Alvera, Ramma Lebogang, Dalvie Sameera, Ramesar Rajkumar S

Abstract excerpt

BACKGROUND: Ototoxicity is an adverse drug reaction that may limit the effective use of cisplatin chemotherapy. Given the reported in vitro protective role of the gene Otos in response to cisplatin, this study aimed to explore the potential of Otos as a genetic modifier of ototoxicity. PATIENTS & METHODS: One hundred South African cisplatin-receiving cancer patients with baseline and follow-up audiometric data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25410892
DOI: 10.2217/pgs.14.112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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