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Article

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.

PloS one - 1 Jan 2011

Leshem Orit, Madar Shalom, Kogan-Sakin Ira, Kamer Iris, Goldstein Ido, Brosh Ran, Cohen Yehudit, Jacob-Hirsch Jasmine, Ehrlich Marcelo, Ben-Sasson Shmuel, Goldfinger Naomi, Loewenthal Ron, Gazit Ephraim, Rotter Varda, Berger Raanan

Abstract excerpt

Prostate cancer is the most common non-dermatologic malignancy in men in the Western world. Recently, a frequent chromosomal aberration fusing androgen regulated TMPRSS2 promoter and the ERG gene (TMPRSS2/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between TMPRSS2/ERG and other defective pathways in cancer progression. However, the unveiling of more specific pathways in which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21747944
DOI: 10.1371/journal.pone.0021650
PMCID: PMC3128608

Genes

ERG
TMPRSS2
ZEB2
ZEB1
CDH1
SPINT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.PMID 21747944Read ↗

The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate CancerSemantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signalingSemantic proximity Read ↗

TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer ProgressionSemantic proximity Read ↗

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer modelsSemantic proximity Read ↗

Oncogenic activation of <i>ERG:</i> A predominant mechanism in prostate cancerSemantic proximity Read ↗

Significance of the TMPRSS2:ERG gene fusion in prostate cancer.Semantic proximity Read ↗

ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cellsSemantic proximity Read ↗

A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cellsSemantic proximity Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and ManagementSemantic proximity Read ↗

TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancerSemantic proximity Read ↗

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