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Article

Optimized expression-based microdissection of formalin-fixed lung cancer tissue.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2017

Grafen Markus, Hofmann Thurid R, Scheel Andreas H, Beck Julia, Emmert Alexander, Küffer Stefan, Danner Bernhard C, Schütz Ekkehard, Büttner Reinhardt, Ostendorf Andreas, Ströbel Philipp, Bohnenberger Hanibal

Abstract excerpt

Analysis of specific DNA alterations in precision medicine of tumors is crucially important for molecular targeted treatments. Lung cancer is a prototypic example and one of the leading causes of cancer-related deaths worldwide. One major technical problem of detecting DNA alterations in tissue samples is cellular heterogeneity, that is, mixture of tumor and normal cells. Microdissection is an important tool to...

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Identifiers

PMID: 28436954
DOI: 10.1038/labinvest.2017.31

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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