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Article

DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2012

Walter Kim, Holcomb Thomas, Januario Tom, Du Pan, Evangelista Marie, Kartha Nithya, Iniguez Leonardo, Soriano Robert, Huw Ling, Stern Howard, Modrusan Zora, Seshagiri Somasekar, Hampton Garret M, Amler Lukas C, Bourgon Richard, Yauch Robert L, Shames David S

Abstract excerpt

PURPOSE: Non-small cell lung cancers (NSCLC) comprise multiple distinct biologic groups with different prognoses. For example, patients with epithelial-like tumors have a better prognosis and exhibit greater sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) pathway than patients with mesenchymal-like tumors. Here, we test the hypothesis that epithelial-like NSCLCs can be distinguished from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22261801
DOI: 10.1158/1078-0432.CCR-11-2635-T

Genes

EGFR
ERBB2
ZEB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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