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Article

Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: a population-based study in China.

Cancer gene therapy - 1 May 2017

Wang H-W, Xu Z-K, Song Y, Liu Y-G

Abstract excerpt

This study aims to investigate the associations of O6-methylguanine-DNA methyltransferase (MGMT) genetic polymorphisms (Leu84Phe and Ile143Val) with temozolomide (TMZ) resistance and prognosis of patients with malignant gliomas. A total of 212 patients diagnosed with malignant gliomas were enrolled in this study as the case group. All of these patients took oral TMZ and were assigned into the TMZ-sensitive...

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Source

Identifiers

PMID: 28409559
DOI: 10.1038/cgt.2017.7

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MGMT

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Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: a population-based study in China.PMID 28409559Read ↗

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