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Article

Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells.

Biochemical and biophysical research communications - 3 Jun 2017

Nakamura Tamami, Hosoyama Tohru, Murakami Junichi, Samura Makoto, Ueno Koji, Kurazumi Hiroshi, Suzuki Ryo, Mikamo Akihito, Hamano Kimikazu

Abstract excerpt

Aging of cardiac stem/progenitor cells (CSCs) impairs heart regeneration and leads to unsatisfactory outcomes of cell-based therapies. As the precise mechanisms underlying CSC aging remain unclear, the use of therapeutic strategies for elderly patients with heart failure is severely delayed. In this study, we used human cardiosphere-derived cells (CDCs), a subtype of CSC found in the postnatal heart, to identify...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

Share to Myocytes, Cardiac

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Source

Identifiers

PMID: 28435069
DOI: 10.1016/j.bbrc.2017.04.110

Genes

SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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