Article
Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations.
Proceedings of the National Academy of Sciences of the United States of America - 2 May 2017
Mattox Austin K, Wang Yuxuan, Springer Simeon, Cohen Joshua D, Yegnasubramanian Srinivasan, Nelson William G, Kinzler Kenneth W, Vogelstein Bert, Papadopoulos Nickolas
Abstract excerpt
The identification of mutations that are present at low frequencies in clinical samples is an essential component of precision medicine. The development of molecular barcoding for next-generation sequencing has greatly enhanced the sensitivity of detecting such mutations by massively parallel seq...
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