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Article

The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.

The Journal of biological chemistry - 9 Jun 2017

Kim Hyoung Tae, Goldberg Alfred L

Abstract excerpt

The proteasome-associated deubiquitinating enzyme Usp14/Ubp6 inhibits protein degradation by catalyzing substrate deubiquitination and by poorly understood allosteric actions. However, upon binding a ubiquitin chain, Usp14 enhances proteasomal degradation by stimulating ATP and peptide degradation. These studies were undertaken to clarify these seemingly opposite regulatory roles of Usp14 and their importance. To...

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Identifiers

PMID: 28416611
DOI: 10.1074/jbc.M116.763128
PMCID: PMC5465503

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