Article
Plasma levels of Apolipoprotein A1 and Lecithin:Cholesterol Acyltransferase in type 2 diabetes mellitus: Correlations with haptoglobin phenotypes.
Diabetes & metabolic syndrome - 1 Dec 2017
Awadallah Samir, Madkour Mohammed, Hamidi Reem Al, Alwafa Esraa Abo, Hattab Maram, Zakkour Buhour, Al-Matroushi Amna, Ahmed Eslah, Al-Kitbi Mariam
Abstract excerpt
BACKGROUND: Previous studies have demonstrated that hemoglobin-haptoglobin (Hb-Hp) complex plays a role in developing vascular complications in type 2 diabetes mellitus (T2DM). The complexes bind with Apolipoprotein A1 (ApoA1) of high-density lipoprotein (HDL), affecting the function of Lecithin:Cholesterol Acyltransferase (LCAT), and impairing the reverse cholesterol transport mechanism (RCT). This study...
Topics
- Adult
- Apolipoprotein A-I
- Cholesterol, HDL
- Diabetes Mellitus, Type 2
- Female
- Haptoglobins
- Humans
- Male
- Middle Aged
- Phenotype
- Phosphatidylcholine-Sterol O-Acyltransferase