Article
Effect of ERCC8 tagSNPs and their association with H. pylori infection, smoking, and alcohol consumption on gastric cancer and atrophic gastritis risk.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2015
Jing Jing-Jing, Sun Li-Ping, Xu Qian, Yuan Yuan
Abstract excerpt
Excision repair cross-complementing group 8 (ERCC8) plays a critical role in DNA repair. Genetic polymorphisms in ERCC8 may contribute to the risk of cancer development. We selected tag single nucleotide polymorphisms (tagSNPs) in Chinese patients from the HapMap database to investigate associations with gastric cancer and its precursors. Genomic DNA was extracted from 394 controls, 394 atrophic gastritis, and...
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