Article
Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.
The Tokai journal of experimental and clinical medicine - 20 Apr 2017
Moriya Yusuke, Nagata Eiichiro, Fujii Natsuko, Satoh Tadayuki, Ogawa Haruko, Hadano Shinji, Takizawa Shunya
Abstract excerpt
OBJECTIVE: Inositol hexakisphosphate kinase 2 (InsP6K2), an enzyme that converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7), induces cell death. InsP6K2 is abundant in the central nervous system, especially anterior horn cells of spinal cord. To identify the role of InsP6K2 in amyotrophic lateral sclerosis (ALS), we investigated the expression levels of InsP6K2 in transgenic...
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