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Article

Acute mast cell leukemia associated with t(4;5)(q21;q33).

Human pathology - 1 Sept 2017

Wang Ren Ching, Ward David, Dunn Philip, Chang Chung-Che

Abstract excerpt

To the best of our knowledge, this manuscript describes clinical and pathologic findings of the first case of acute mast cell leukemia harboring t(4;5)(q21;q33), compatible with fusion of the PDGFRB gene to a rare partner, PRKG2. Translocation involving the PDGFRB gene is confirmed by fluorescence in situ hybridization study. This case presented a relatively fulminant clinical course with acute mast cell leukemia...

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Topics

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Share to Chromosomes, Human, Pair 4
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Share to Gene Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imatinib Mesylate

Share to Molecular Diagnostic Techniques

Share to Receptor, Platelet-Derived Growth Factor beta

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Share to Translocation, Genetic

Source

Identifiers

PMID: 28412213
DOI: 10.1016/j.humpath.2017.03.014

Genes

PDGFRB
PRKG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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