Article
Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1.
Annals of hematology - 1 Jun 2013
Patterer Verena, Schnittger Susanne, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia
Abstract excerpt
The translocation t(8;9)(p22;p24) is a rare event that results in the fusion of JAK2 to PCM1 and thus leads to the activation of the Janus Kinase 2. In 2008, the WHO introduced a new entity called "Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1", which are characterized by the formation of a fusion gene encoding an aberrant tyrosine kinase. These disorders share...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.