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Article

A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation.

Heart rhythm - 1 Oct 2008

Benito Begoña, Brugada Ramon, Perich Rosa Maria, Lizotte Eric, Cinca Juan, Mont Lluis, Berruezo Antonio, Tolosana José María, Freixa Xavier, Brugada Pedro, Brugada Josep

Abstract excerpt

BACKGROUND: Type 3 long-QT syndrome (LQT-3) is caused by gain-of-function mutations in the SCN5A encoding the cardiac sodium channel. Familial atrial fibrillation (AF), previously considered a potassium channelopathy, has recently been related to sodium genetic variants, both in isolated forms an...

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Identifiers

PMID: 18929331
DOI: 10.1016/j.hrthm.2008.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18929331-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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