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Article

Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel.

Cardiovascular research - 1 Mar 2008

Surber Ralf, Hensellek Sabine, Prochnau Dirk, Werner Gerald S, Benndorf Klaus, Figulla Hans R, Zimmer Thomas

Abstract excerpt

AIMS: The aim of the present study was to elucidate the molecular mechanism underlying the concomitant occurrence of cardiac conduction disease and long QT syndrome (LQT3), two SCN5A channelopathies that are explained by loss-of-function and gain-of-function, respectively, in the cardiac Na+ channel. METHODS AND RESULTS: A Caucasian family with prolonged QT interval, intermittent bundle-branch block, sudden...

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PMID: 18065446
DOI: 10.1093/cvr/cvm096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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