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Article

Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.

Circulation research - 15 Aug 2008

Barajas-Martínez Hector M, Hu Dan, Cordeiro Jonathan M, Wu Yuesheng, Kovacs Richard J, Meltser Henry, Kui Hong, Elena Burashnikov, Brugada Ramon, Antzelevitch Charles, Dumaine Robert

Abstract excerpt

Brugada syndrome has been linked to mutations in SCN5A. Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tachycardia/fibrillation. Lidocaine, an agent with rapid dissociation kinetics, has previously been shown to exert no effect in patients with Brugada syndrome. We characterized a novel double mutation...

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Identifiers

PMID: 18599870
DOI: 10.1161/CIRCRESAHA.108.172619
PMCID: PMC2575042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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