Article
TUFT1, a novel candidate gene for metatarsophalangeal osteoarthritis, plays a role in chondrogenesis on a calcium-related pathway.
PloS one - 1 Jan 2017
Sliz Eeva, Taipale Mari, Welling Maiju, Skarp Sini, Alaraudanjoki Viivi, Ignatius Jaakko, Ruddock Lloyd, Nissi Ritva, Männikkö Minna
Abstract excerpt
Osteoarthritis (OA) is the most common degenerative joint disorder and genetic factors have been shown to have a significant role in its etiology. The first metatarsophalangeal joint (MTP I) is highly susceptible to development of OA due to repetitive mechanical stress during walking. We used whole exome sequencing to study genetic defect(s) predisposing to familial early-onset bilateral MTP I OA inherited in an...
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