Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance.

Abstract excerpt

For over four decades structural biology has been used to understand the mechanisms of disease, and structure-guided approaches have demonstrated clearly that they can contribute to many aspects of early drug discovery, both computationally and experimentally. Structure can also inform our understanding of impacts of mutations in human genetic diseases and drug resistance in cancers and infectious diseases. We...

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