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Article

Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants.

Neurochemistry international - 1 Oct 2017

Lopez-Fabuel Irene, Martin-Martin Lucia, Resch-Beusher Monica, Azkona Garikoitz, Sanchez-Pernaute Rosario, Bolaños Juan P

Abstract excerpt

Brain mitochondrial complex I (CI) damage is associated with the loss of the dopaminergic neurons of the Substantia Nigra in Parkinson's Disease (PD) patients. However, whether CI inhibition is associated with any alteration of the mitochondrial respiratory chain (MRC) organization in PD patients is unknown. To address this issue, here we analyzed the MRC by blue native gel electrophoresis (BNGE) followed by...

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Source

Identifiers

PMID: 28408307
DOI: 10.1016/j.neuint.2017.03.023

Genes

PINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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