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Article

Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases.

Biochimica et biophysica acta - 1 May 2009

Papa Sergio, Petruzzella Vittoria, Scacco Salvatore, Sardanelli Anna Maria, Iuso Arcangela, Panelli Damiano, Vitale Rita, Trentadue Raffaella, De Rasmo Domenico, Capitanio Nazzareno, Piccoli Claudia, Papa Francesco, Scivetti Michele, Bertini Enrico, Rizza Teresa, De Michele Giuseppe

Abstract excerpt

This paper covers genetic and biochemical aspects of mitochondrial bioenergetics dysfunction in hereditary neurological disorders associated with complex I defects. Three types of hereditary complex I dysfunction are dealt with: (i) homozygous mutations in the nuclear genes NDUFS1 and NDUFS4 of c...

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Source

Identifiers

PMID: 19210954
DOI: 10.1016/j.bbabio.2008.12.018

Genes

NDUFS1
NDUFS4
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19210954-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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