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Article

Strain improvement of Lentzea sp. 7887 for higher yield per unit volume on hydroxylation of cyclosporine derivative FR901459.

Bioscience, biotechnology, and biochemistry - 1 Jul 2017

Yabutani Tetsuya, Tsujimoto Mami, Ohira Shunsuke, Shimizu Shiho, Nakano Hideo

Abstract excerpt

A Gram-positive bacterium Lentzea sp. 7887 hydroxylates a cyclosporine derivative FR901459 into AS1837812 (9-hydroxide), which is an important intermediate of candidate drugs that target the hepatitis C virus. We screened a UV-induced mutant, named M-1, which showed about 1.2-fold higher conversion yields, 2-fold higher substrate concentrations (3.69 mM), and 2.5-fold higher yield per unit volume than the...

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Identifiers

PMID: 28406069
DOI: 10.1080/09168451.2017.1314759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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