Article
Components of the folate metabolic pathway and ADHD core traits: an exploration in eastern Indian probands.
Journal of human genetics - 1 Jul 2017
Saha Tanusree, Chatterjee Mahasweta, Sinha Swagata, Rajamma Usha, Mukhopadhyay Kanchan
Abstract excerpt
We investigated role of the folate-homocysteine metabolic pathway in the etiology of attention-deficit hyperactivity disorder (ADHD) due to its importance in maintaining DNA integrity as well as neurotransmission. Functional gene variants in MTR (rs1805087), CBS (rs5742905), MTHFR (rs1801133 &rs1801131), MTHFD (rs2236225), RFC1 (), plasma vitamin B12, folate and homocysteine were analyzed. 'A'...
