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Article

Associations of Polymorphisms in MTHFR Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis.

PloS one - 1 Jan 2015

Wang Xue-bin, Qiao Chen, Wei Li, Han Ya-di, Cui Ning-hua, Huang Zhu-liang, Li Zu-hua, Zheng Fang, Yan Ming

Abstract excerpt

Homocysteine (Hcy) is a potential risk factor for age-related cataract (ARC). Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme for Hcy metabolism, and variants of MTHFR may affect MTHFR enzyme activity. This study mainly evaluated the associations between variants in MTHFR gene, plasma MTHFR enzyme activity, total Hcy (tHcy) levels and ARC risk in Chinese population. Four single nucleotide...

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Identifiers

PMID: 26689687
DOI: 10.1371/journal.pone.0145581
PMCID: PMC4686960

Genes

MTHFR
ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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