Article
Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms.
Experimental eye research - 1 May 2025
Ratnapriya Rinki, Grassman Felix, Chen Rui, Hewitt Alex, Du Jianhai, Saban Daniel R, Klaver Caroline C W, Ash John, Stambolian Dwight, Tumminia Santa J, Qian Jiang, Husain Deeba, Iyengar Sudha K, den Hollander Anneke I
Abstract excerpt
Genome-wide association studies have been remarkably successful in identifying genetic variants associated with age-related macular degeneration (AMD), demonstrating a strong genetic component largely driven by common variants. However, progress in translating these genetic findings into a deeper understanding of disease mechanisms and new therapies has been slow. Slow progress in this area can be attributed to...
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