Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl‑1 pathway.

International journal of oncology - 1 May 2017

Qu Ning, Hu Jia-Qian, Liu Liang, Zhang Ting-Ting, Sun Guo-Hua, Shi Rong-Liang, Ji Qing-Hai

Abstract excerpt

Sirtuin 6 (SIRT6) is a member of the SIRT family NAD+‑dependent deacetylases reported to function in controlling organism homeostasis, lifespan, and diseases. This study investigated the role of SIRT6 in papillary thyroid cancer (PTC). Data of 391 PTC patients was extracted from The Cancer Genome Atlas database to investigate the expression of SIRTs (SIRT1‑7) and their relationship with clinicopathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to MAP Kinase Signaling System

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Sirtuins

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 28393212
DOI: 10.3892/ijo.2017.3951

Genes

SIRT6
BRAF
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl‑1 pathway.PMID 28393212Read ↗

SIRT1 Expression and BRAF V600E Mutation in Papillary Thyroid Cancer: Implications for Diagnosis and PrognosisSemantic proximity Read ↗

SIRT7 affects the proliferation and apoptosis of papillary thyroid cancer cells by desuccinylation of LATS1Semantic proximity Read ↗

SIX1 Expression and its Clinicopathological Significance: Difference between Classic and Follicular Variant Papillary Thyroid CarcinomaSemantic proximity Read ↗

Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinomaSemantic proximity Read ↗

Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cellsSemantic proximity Read ↗

STRA6 regulates tumor immune microenvironment and is a prognostic marker in BRAF-mutant papillary thyroid carcinomaSemantic proximity Read ↗

MicroRNAs miR-146-5p and let-7f as prognostic tools for aggressive papillary thyroid carcinoma: a case report.Semantic proximity Read ↗

SIRT3 Expression Predicts Overall Survival and Neoadjuvant Chemosensitivity in Triple-Negative Breast CancerSemantic proximity Read ↗

MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer.Semantic proximity Read ↗

PSD3 is an oncogene that promotes proliferation, migration, invasion, and G1/S transition while inhibits apoptotic in papillary thyroid cancerSemantic proximity Read ↗

SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.