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Compartmentalization of DNA Damage Response between Heterochromatin and Euchromatin Is Mediated by Distinct H2A Histone Variants.

Current biology : CB - 24 Apr 2017

Lorković Zdravko J, Park Chulmin, Goiser Malgorzata, Jiang Danhua, Kurzbauer Marie-Therese, Schlögelhofer Peter, Berger Frédéric

Abstract excerpt

DNA double-strand break (DSB) repair depends on the ataxia telangiectasia mutated (ATM) kinase that phosphorylates the conserved C-terminal SQ motif present in the histone variant H2A.X [1-7]. In constitutive heterochromatin of mammals, DSB repair is delayed and relies on phosphorylation of the proteins HP1 and KAP1 by ATM [2, 8-14]. However, KAP1 is not conserved in plants and the HP1-related protein Like-HP1...

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PMID: 28392109
DOI: 10.1016/j.cub.2017.03.002

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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