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Article

The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation.

Nature communications - 11 May 2021

Bourguet Pierre, Picard Colette L, Yelagandula Ramesh, Pélissier Thierry, Lorković Zdravko J, Feng Suhua, Pouch-Pélissier Marie-Noëlle, Schmücker Anna, Jacobsen Steven E, Berger Frédéric, Mathieu Olivier

Abstract excerpt

In flowering plants, heterochromatin is demarcated by the histone variant H2A.W, elevated levels of the linker histone H1, and specific epigenetic modifications, such as high levels of DNA methylation at both CG and non-CG sites. How H2A.W regulates heterochromatin organization and interacts with other heterochromatic features is unclear. Here, we create a h2a.w null mutant via CRISPR-Cas9, h2a.w-2, to analyze...

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Identifiers

PMID: 33976212
DOI: 10.1038/s41467-021-22993-5
PMCID: PMC8113232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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